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The Apolipoprotein E E4 Allele and Sex-Specific Risk of Alzheimer's Disease-Reply

Haydeh Payami, PhD; Kim R. Montee; Jeffrey A. Kaye, MD; Ellen M. Wijsman, PhD; Thomas Bird, MD; Chang-En Yu, PhD; Leonard L. Heston, MD; Gerard D. Schellenberg, PhD
JAMA. 1995;273(5):374. doi:10.1001/jama.1995.03520290025014.
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In Reply.  —We originally reported data on late-onset familial AD that showed a significantly (P=.004) higher risk for women with one apo E E4 allele than for men with one E4 allele. In their letter, Dr Corder and colleagues report no significant difference between men and women in their late-onset familial and sporadic AD data. Lack of evidence in sporadic AD is not surprising; we had suspected that the gender difference may be present only in the familial cases. However, it is puzzling that they did not find the same strong gender difference that we did in the familial cases. According to Figures 1 and 2 of their letter, by 85 years of age nearly 100% of women with one E4 allele were affected as compared with 50% of men with one E4 allele, but the overall difference was not statistically significant (P=.12), possibly indicative of small sample


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