0
ARTICLE |

Outbreak of Group A Streptococcus Septicemia in Children:  Clinical, Epidemiologic, and Microbiological Correlates

Mary C. Wheeler, MA; Martha H. Roe; Edward L. Kaplan, MD; Patrick M. Schlievert, PhD; James K. Todd, MD
JAMA. 1991;266(4):533-537. doi:10.1001/jama.1991.03470040097029.
Text Size: A A A
Published online

Objective.  —To determine the epidemiologic, clinical, and microbiological features of group A streptococcus septicemia in children.

Design.  —A descriptive series of 34 cases over an 11-year period from 1980 through 1990.

Setting.  —An academically affiliated tertiary-care pediatric hospital, the principal referral center for the state of Colorado and surrounding states.

Participants.  —Thirty-four patients with positive blood cultures for group A streptococcus (33 medical records were available).

Main Outcome Measures.  —Yearly incidence and clinical features of cases; microbiological features of isolated organisms.

Results.  —There was a significant increase (P =.01) in the incidence of group A streptococcus bacteremia over an 11-year period, with 14 (41%) of these cases occurring in 1989 and 1990. Patients had a rapidly progressing illness, usually without preceding pharyngitis. The prominent M and T types were 1 (4) and 12 (4). Eleven (73%) of the 15 strains produced pyrogenic exotoxin B that significantly correlated with production of proteinase.

Conclusion.  —There appears to be an increase in group A streptococcus bacteremia in children that is associated with a strain phenotype that suggests a change in organism virulence.(JAMA. 1991;266:533-537)

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

Figures

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();