0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Estrogen Replacement Therapy and Risk of Breast Cancer

William D. Dupont, PhD
JAMA. 1991;265(14):1824. doi:10.1001/jama.1991.03460140052012.
Text Size: A A A
Published online

To the Editor. —  Colditz et al1 have made a significant contribution to our knowledge of the relationship between estrogen replacement therapy and breast cancer. I do not, however, share the authors' confidence that their results were unaffected by bias due to increased surveillance of estrogen users. Among never users, the crude incidence of breast cancer was 354 cases in 186 466 women, or 190 per 100 000 women per year (see Table 2 of Colditz et al). If current users had also had this incidence, the authors would have observed 144 breast cancers during 75 643 person-years of follow-up in the current user group. In fact, they observed 180 cases, 36 more than expected. It is plausible that these 36 excess cancers might be due to increased surveillance for breast cancer. In late 1974, publicity surrounded the diagnosis of breast cancer in the wives of the president and

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Figures

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();