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Lowering Lipids Improves Coronary Arterial Anatomy

Edward Attarian, MD, PA
JAMA. 1991;265(13):1688-1689. doi:10.1001/jama.1991.03460130080024.
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To the Editor.—  I am writing to express my deep concern about the article by Kane et al1 concerning regression of coronary atherosclerosis by drug treatment of familial hypercholesterolemia. In the section under "Results" regarding regression vs progression, the authors indicate that there was "a strong but not statistically significant" difference. And yet their conclusions state that the treatment of the patients did indeed result in improvement.In the next article in the same issue of JAMA, Cashin-Hemphill et al2 also came to the same conclusion, although they stated there were "no significant differences in major medical events experienced over the 4-year study of the period." I believe we are doing a disservice to the American public when we are spending millions of dollars to control cholesterol, and yet there are no statistical data to prove that we do in fact prolong life.I see this as one


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