We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Mismatched marrow grafts succeed thanks to two anti-T-cell agents

Beverly Merz
JAMA. 1983;249(13):1687-1689. doi:10.1001/jama.1983.03330370003001.
Text Size: A A A
Published online


The A. he patient died, but—the old story—the therapy was a success. Indeed, an Associated Press story heralded the treatment as a major medical break-through. The story, which hit newsstands across the nation on February 15, began hyperbolically, "For the first time, doctors have cured a deadly assault on the body's immune system, saving the life of a week-old baby with an experimental treatment called monoclonal antibodies."

The article was referring to the treatment of Bryan Ahlers, who during surgery to repair a heart defect three days after his birth at Children's Hospital, Buffalo, NY, was given a routine blood transfusion. When rash, fever, diarrhea, and ascites developed, immunologist Byung H. Park, MD, recognized the classic symptoms of graft v host disease (GVHD). This seemed an unlikely response until physicians discovered that Bryan had no thymus. With no mature T lymphocytes of his own, the lymphocytes in the transfused blood


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.