Reye Syndrome Surveillance—United States, 1989

JAMA. 1991;265(8):960. doi:10.1001/jama.1991.03460080028009.
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Barrett MJ, Hurwitz ES, Schonberger LB, Rogers MF.  Changing epidemiology of Reye syndrome in the United States . Pediatrics 1986;77:598-602.
Hurwitz ES, Barrett MJ, Bregman D, et al.  Public Health Service study on Reye's syndrome and medications: report of the pilot phase . N Engl J Med 1985;313:849-57.
Link to Article[[XSLOpenURL/10.1056/NEJM198510033131403]]
Hurwitz ES, Barrett MJ, Bregman D, et al.  Public Health Service study of Reye's syndrome and medications: report of the main study . JAMA 1987;257:1905-11.
Link to Article[[XSLOpenURL/10.1001/jama.1987.03390140075030]]
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Link to Article[[XSLOpenURL/10.1001/jama.1988.03410050077033]]
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Link to Article[[XSLOpenURL/10.1001/jama.1982.03320470035029]]
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Link to Article[[XSLOpenURL/10.1001/jama.1982.03330060027028]]
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Link to Article[[XSLOpenURL/10.1016/0002-9343(76)90139-X]]
Hurwitz ES.  The changing epidemiology of Reye's syndrome in the United States: further evidence for a public health success (Editorial) . JAMA 1988;260:3178-80.
Link to Article[[XSLOpenURL/10.1001/jama.1988.03410210090045]]
Rowe PC, Valle D, Brusilow SW.  Inborn errors of metabolism in children referred with Reye's syndrome: a changing pattern . JAMA 1988;260:3167-70.
Link to Article[[XSLOpenURL/10.1001/jama.1988.03410210079041]]
According to CDC's case definition, the following conditions must be met for consideration as a RS case: 1) acute, noninflammatory encephalopathy documented a) by alteration in the level of consciousness and, if available, a record of cerebrospinal fluid containing ≤8 leukocytes per mm3 or b) by histologic specimen demonstrating cerebral edema without perivascular or meningeal inflammation; 2) hepatopathy documented either by a liver biopsy or autopsy considered to be diagnostic of RS or by a threefold or greater rise in the levels of either serum aspartate aminotransferase, serum alanine aminotransferase, or serum ammonia; and 3) no more reasonable explanation for the cerebral and hepatic abnormalities.


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