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Reye Syndrome Surveillance—United States, 1989

JAMA. 1991;265(8):960. doi:10.1001/jama.1991.03460080028009.
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Barrett MJ, Hurwitz ES, Schonberger LB, Rogers MF.  Changing epidemiology of Reye syndrome in the United States . Pediatrics 1986;77:598-602.
Hurwitz ES, Barrett MJ, Bregman D, et al.  Public Health Service study on Reye's syndrome and medications: report of the pilot phase . N Engl J Med 1985;313:849-57.
Link to Article[[XSLOpenURL/10.1056/NEJM198510033131403]]
Hurwitz ES, Barrett MJ, Bregman D, et al.  Public Health Service study of Reye's syndrome and medications: report of the main study . JAMA 1987;257:1905-11.
Link to Article[[XSLOpenURL/10.1001/jama.1987.03390140075030]]
Pinsky PF, Hurwitz ES, Schonberger LB, Gunn WJ.  Reye's syndrome and aspirin: evidence for a dose-response effect . JAMA 1988;260:657-61.
Link to Article[[XSLOpenURL/10.1001/jama.1988.03410050077033]]
Starko KM, Ray CG, Dominguez LB, Stromberg WL, Woodall DF.  Reye's syndrome and salicylate use . Pediatrics 1980;66:859-64.
Waldman RJ, Hall WN, McGee H, Van Amburg G.  Aspirin as a risk factor in Reye's syndrome . JAMA 1982;247:3089-94.
Link to Article[[XSLOpenURL/10.1001/jama.1982.03320470035029]]
Halpin TJ, Holtzhauer FJ, Campbell RJ, et al.  Reye's syndrome and medication use . JAMA 1982;248:687-91.
Link to Article[[XSLOpenURL/10.1001/jama.1982.03330060027028]]
Remington PL, Rowley D, McGee H, Hall WN, Monto AS.  Decreasing trends in Reye syndrome and aspirin use in Michigan, 1979 to 1984 . Pediatrics 1986;77:93-8.
Arrowsmith JB, Kennedy DL, Kuritsky JN, Faich GA.  National patterns of aspirin use and Reye syndrome reporting, United States, 1980 to 1985 . Pediatrics 1987;79:858-63.
Corey L, Rubin RJ, Hattwick MAW, Noble GR, Cassidy E.  A nationwide outbreak of Reye's syndrome: its epidemiologic relationship to influenza B . Am J Med 1976;61:615-25.
Link to Article[[XSLOpenURL/10.1016/0002-9343(76)90139-X]]
Hurwitz ES.  The changing epidemiology of Reye's syndrome in the United States: further evidence for a public health success (Editorial) . JAMA 1988;260:3178-80.
Link to Article[[XSLOpenURL/10.1001/jama.1988.03410210090045]]
Rowe PC, Valle D, Brusilow SW.  Inborn errors of metabolism in children referred with Reye's syndrome: a changing pattern . JAMA 1988;260:3167-70.
Link to Article[[XSLOpenURL/10.1001/jama.1988.03410210079041]]
According to CDC's case definition, the following conditions must be met for consideration as a RS case: 1) acute, noninflammatory encephalopathy documented a) by alteration in the level of consciousness and, if available, a record of cerebrospinal fluid containing ≤8 leukocytes per mm3 or b) by histologic specimen demonstrating cerebral edema without perivascular or meningeal inflammation; 2) hepatopathy documented either by a liver biopsy or autopsy considered to be diagnostic of RS or by a threefold or greater rise in the levels of either serum aspartate aminotransferase, serum alanine aminotransferase, or serum ammonia; and 3) no more reasonable explanation for the cerebral and hepatic abnormalities.

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