0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Alzheimer's-Linked Protein Found to Be Skin Deep, but Potential New Therapies See Beauty of It

Teri Randall
JAMA. 1991;265(3):309-310. doi:10.1001/jama.1991.03460030011003.
Text Size: A A A
Published online

ABSTRACT

THE BRAIN no longer corners the amyloid β-protein market. Sensitive assays have recently detected the notorious protein in several nonneural tissues of patients with Alzheimer's disease, including the skin, intestine, and adrenal gland. Researchers say the discovery has major implications for the pathogenesis and treatment of this disease.

The finding has come as a surprise to investigators, even to the researchers at Harvard Medical School, Boston, Mass, who conducted the experiments. "It has always been assumed, since Alzheimer described the disease in 1906, that it involved only the brain," says Dennis Selkoe, MD, codirector of Brigham and Women's Hospital's Center for Neurologic Diseases and professor of neurology and neuroscience at Harvard.

The subclinical deposition of small amounts of amyloid β-protein in nonneural tissues lends support to the hypothesis, yet to be proven, that this protein originates in the bloodstream, or is produced locally in a variety of organs.

New Assay 

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Figures

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();