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Nephrotic Syndrome

George Dunea, MD
JAMA. 1983;249(8):1065-1066. doi:10.1001/jama.1983.03330320063043.
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In the four years since I reviewed the first volume of Contemporary Issues in Nephrology, the little red books have kept coming at roughly six-month intervals, so that there are now nine of them. Complete, up to date, and extensively referenced, they cover a subject in roughly 300 pages, offering the student of renal diseases a useful aid for keeping up with modern developments.

The present volume concerns itself with proteinuria, glomerulonephritis, and the nephrotic syndrome. It starts off with a difficult chapter by a professor of chemical engineering on the morphological and functional basis of proteinuria, emphasizing that macromolecules pass through the glomerular filter not only according to their size but also depending on their electrical charge and perhaps even on their configuration. Then follows a chapter on the mechanism of edema, which covers the pathogenesis of hypoalbuminemia and presents the current view that effective plasma volume in the


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