We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Dobutamine Overdose

Paul M. Paulman, MD; Kimberly Cantral, PharmD; Jeffrey G. Meade, MD; Kenneth Vettel, MD; Rudolph Loperena, MD; Murray Odrezin, MD
JAMA. 1990;264(18):2386-2387. doi:10.1001/jama.1990.03450180042022.
Text Size: A A A
Published online


To the Editor.—  An inadvertent overadministration of intravenous dobutamine recently occurred at our hospital. A 47-year-old woman, admitted for urosepsis, mistakenly received another patient's dobutamine instead of the intravenous antibiotics ordered. Although the dobutamine was labeled appropriately, this medication was hung and administered to the patient at more than 130 μg/kg per minute for 30 minutes. This rate is three times the recommended maximum intravenous dosage (40 μg/kg per minute) and approximately 150% of the previously reported maximum dose of 80 μg/kg per minute.1The error was discovered by the nursing staff within minutes of completion of the dobutamine infusion, and the house officer on call was notified. On initial evaluation, the patient complained of being very anxious and "jittery." Her blood pressure was 170/80 mm Hg with a baseline of 108/60 mm Hg. She was also tachycardic (120 beats per minute) and tachypneic (respirations, 30/min). The patient complained


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.