We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

The Toxicity and Dose of Desipramine Hydrochloride-Reply

J. John Mann, MD
JAMA. 1994;272(22):1720-1721. doi:10.1001/jama.1994.03520220013007.
Text Size: A A A
Published online


In Reply.  —Drs Amitai and Frischer agree with our report that desipramine is more lethal on overdose than other tricyclics. Amitai et al1 found that the in vitro RBC/plasma ratio of desipramine (1.60) was no different from nortriptyline (1.57) or nordoxepin (1.62); parent compounds had lower ratios (eg, 0.73 for imipramine and 0.45 for amitriptyline). In vivo, their results1 in cases of drug overdose are consistent and suggest that the parent compound washes out of RBCs and plasma faster than the desmethyl metabolite, and that the parent compound, more so than the metabolite, is found in higher concentrations in the plasma than the RBCs. However, the presence of coma was unrelated to plasma or RBC concentrations of parent drug or metabolite. The duration of the QRS interval correlated with RBC and plasma levels of metabolite, but not parent compound. Therefore, these results do not demonstrate that the RBC/plasma


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.