0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Apolipoprotein E Alleles, Dyslipidemia, and Coronary Heart Disease:  The Framingham Offspring Study

Peter W. F. Wilson, MD; Richard H. Myers, PhD; Martin G. Larson, ScD; Jose M. Ordovas, PhD; Philip A. Wolf, MD; Ernst J. Schaefer, MD
JAMA. 1994;272(21):1666-1671. doi:10.1001/jama.1994.03520210050031.
Text Size: A A A
Published online

Objective.  —To describe the association between apolipoprotein E alleles (ε2, ε3, and ε4), dyslipidemias, and coronary heart disease (CHD).

Design.  —Cross-sectional prevalence study.

Setting and Participants.  —Community-based sample of men (n=1034) and women (n=916) aged 40 to 77 years who are participating in a long-term study of cardiovascular disease. Study participants underwent fasting lipid measurements, coronary risk factor determinations, and a comprehensive evaluation for the presence of current or previous CHD.

Results.  —Compared with the ε3 allele, the ε4 allele was associated with elevated low-density lipoprotein cholesterol values (≥4.14 mmol/L [160 mg/dL]) in women, the ε2 and ε4 alleles were associated with moderately elevated triglyceride values (≥2.82 mmol/L [250 mg/dL]) in men, and the ε2 allele was associated with severely elevated triglyceride values (≥5.64 mmol/L [500 mg/dL]) in men. The apolipoprotein E alleles were not associated with hypertension, obesity, smoking, or diabetes, but the ε4 allele frequency was reduced in women after 60 years of age. The age-adjusted prevalence of CHD was associated with the ε4 allele in both men (relative odds=1.53, P=.04) and women (relative odds=1.99, P=.05). In analyses for women and for both sexes combined, this relation persisted after adjustment by hypertension, smoking, obesity, diabetes, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol.

Conclusions.  —Apolipoprotein E alleles are important genetic markers for dyslipidemia and CHD. The estimated CHD odds associated with the ε4 allele appears to be greater than that for any other known genetic lipid abnormality, and the association of the ε4 allele with CHD remains significant in women and both sexes combined after adjustment by traditional coronary risk factors and lipids.(JAMA. 1994;272:1666-1671)

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Figures

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();