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Sexual Differences in Cancer Survival: Hormones or Stage at Diagnosis?

Julianne Byrne, PhD; Thomas R. Fears, PhD; H. Stacy Nicholson, MD
JAMA. 1990;264(14):1810. doi:10.1001/jama.1990.03450140030022.
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To the Editor.—  We attempted to confirm the finding of Adami et al1 in our cohort of long-term survivors of childhood and adolescent cancer, described more fully elsewhere.2 Between 1980 and 1983 we interviewed 2300 long-term (>5 years after diagnosis and ≥21 years of age) survivors of cancer diagnosed before the age of 20 years or their proxies. The survivors were 32 years old on average at the time of follow-up and had been diagnosed at an average age of 14.5 years. In this cohort analysis we evaluated mortality in survivors starting from the time when they became eligible for the cohort as defined above. Hazard rates within categories were calculated as the number of events divided by the estimated person-years of follow-up, and significance tests assumed that rates were constant across 5-year periods.We found, as did Adami et al, that compared with males, female survivors were


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