0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Allelic Association of Human Dopamine D2 Receptor Gene in Alcoholism

A. G. Motulsky, MD, DSc
JAMA. 1990;264(14):1807-1808. doi:10.1001/jama.1990.03450140027014.
Text Size: A A A
Published online

To the Editor.—  The rationale, design, and biologic significance of association studies of genetic markers in disease need to be understood to evaluate claims for the role of a dopamine receptor gene in alcoholism.1A DNA variant or restriction fragment length polymorphism for a dopamine-2 receptor gene has been described.2 The frequencies of allele 1 and allele 2 were 0.24 and 0.76, respectively, in a normal population. The probe used and extensive knowledge about the sites of restriction fragment length polymorphisms in DNA suggest that this alteration affects noncoding DNA. Such DNA markers are frequent and usually have no biologic function. Blum et al1 used this probe in 35 brain DNA specimens from nonalcoholics and found allele 1 and 2 frequencies of 0.13 and 0.87, respectively. In contrast, among brain samples from 35 alcoholics the frequencies of allele 1 and allele 2 were 0.37 and 0.63, respectively. Based

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Figures

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();