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Long Struggle Continues to Find New Weapons Against an Old Foe—the Malaria Parasite

Charles Marwick
JAMA. 1990;263(20):2718. doi:10.1001/jama.1990.03440200016004.
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PROTECTION against the malaria parasite is a highly complex affair that has hindered the development of an effective vaccine against the disease.

Despite the contributions of the molecular biologist in isolating, cloning, and manufacturing, by recombinant techniques, immunologic pieces of the parasite, and the testing of one recombinant gene-cloned vaccine (which stimulated only low levels of antibody), the goal of an effective immunogen against malaria seems as far off as ever.

But if the goal remains distant, this isn't deterring a determined cadre of malaria researchers from pursuing it, if the amount and variety of research reported at a recent workshop on cellular mechanisms in malaria immunity—held by the John E. Fogarty International Center staff at the National Institutes of Health campus in Bethesda, Md—is any evidence.

Pace Picking Up  "The field is moving so rapidly, I sometimes have difficulty myself seeing what's important and what isn't," admits Peter Perlmann,


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