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Cryotherapy in Infants With Retinopathy of Prematurity-Reply

Dale L. Phelps, MD; Charles E. Phelps, PhD
JAMA. 1990;263(15):2052. doi:10.1001/jama.1990.03440150056026.
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In Reply.—  Dr Hindle emphasizes the importance of each ophthalmologist developing critical judgment in the care of premature infants' eyes, and we agree. Such judgment depends on training, on experience, and, fortunately, increasingly on testing of scientific hypotheses and formal decision-making models. The cryotherapy-ROP trial continues to collect data comparing the visual outcome and long-term side effects of treated eyes with randomly selected untreated eyes with ROP. This factual database will enhance each physician's ability to form his or her own critical judgment.For the interim, based on published data, our analysis used a standard medical decision model to explore the complex treatment choice of none vs one vs two eyes. Such models always contain assumptions; a key part of the analysis seeks to learn which of the yet unknown parameters of the model most critically alter the treatment decision. In our model, we assigned these values based on discussions


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