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Parental History and Myopia: Taking the Long View-Reply

Karla Zadnik, OD, PhD; Donald O. Mutti, OD, PhD; Anthony J. Adams, OD, PhD; William A. Satariano, PhD; Robert I. Sholtz, MS
JAMA. 1994;272(16):1256. doi:10.1001/jama.1994.03520160039038.
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In Reply.  —We appreciate the responses of Drs Chew and Ritch and Dr Wallman to our work. We agree that there is still much work to be done in the important area of myopia development. While our report represents cross-sectional results from a 7-year longitudinal investigation of juvenileonset myopia, we believe that our original discussion was fair and measured and that our conclusions were based on standard analytic techniques.Recent research, based on lower vertebrates,1 has been designed to look exclusively at environmental causes of myopia. We believe our work in humans suggests the possible significance of genetic factors, an area that has received little research attention since 1978.Wallman raised the possibility of parents' refractive error being related to a child's propensity for near work. We assessed near work and parental refractive error history in the same statistical model, with an analysis designed to give the relevant variables


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