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Therapy for Low High-Density Lipoprotein Cholesterol in the Face of 'Desirable' Levels of Total Cholesterol-Reply

Gloria Lean Vega, PhD; Scott M. Grundy, MD, PhD
JAMA. 1990;263(13):1768. doi:10.1001/jama.1990.03440130048025.
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In Reply. —  Dr Miller points out that our definition of normolipidemia included total cholesterol levels below 6.47 mmol/L and was not restricted to levels below 5.2 mmol/L, which have been called "desirable" cholesterol levels by the National Cholesterol Education Program. He suggests that our findings for the latter category would be of interest. In response, our patient group included 13 patients in whom total cholesterol levels were in the desirable range (<5.2 mmol/L) at the time of entry into the study. The results for these patients are summarized in the Table.The direction and magnitudes of changes were similar for those with cholesterol levels below 5.20 mmol/L and for the whole group with levels below 6.47 mmol/L. Therefore, it appears that the conclusions drawn for the whole group can be extended to patients with low high-density lipoprotein cholesterol levels in whom total cholesterol levels are in the desirable range,


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