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End-Tidal Pco2 During Cardiopulmonary Resuscitation-Reply

Arthur B. Sanders, MD; Karl B. Kern, MD; Charles W. Otto, MD; Melinda M. Milander, RN; Gordon A. Ewy, MD
JAMA. 1990;263(6):815. doi:10.1001/jama.1990.03440060054031.
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In Reply.—  We appreciate the comments of Weil et al and Dr Yetiv regarding our recent article. Weil et al noted the potential importance of the continuous measurement of end-tidal carbon dioxide tension (PETCO2) during cardiopulmonary resuscitation (CPR). We agree and note that PETCO2 was continuously monitored in all 35 patients reported. Trends in PETCO2 were reported in Fig 2 of the article. Patients who were not successfully resuscitated showed a steady and significant decline in PETCO2, while successfully resuscitated patients showed an increase in PETCO2 that was not statistically significant.We caution the reader, however, about making conclusions that our experimental methodology was not designed to test. We demonstrated a strong clinical association between PETCO2 during ongoing CPR efforts and resuscitation and survival from cardiac arrest. It remains to be demonstrated


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