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Kaposi's Sarcoma, Vascular Permeability, and Scientific Integrity-Reply

Marlys H. Witte, MD; Peter Borgs, PhD; Dennis L. Way; Michael Bernas, MS; Geronimo Ramirez Jr, MD; Charles L. Witte, MD
JAMA. 1994;272(12):922-924. doi:10.1001/jama.1994.03520120026025.
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In Reply.  —Our JAMA article, in keeping with our original correspondence with Science on April 24,1992, July 30,1992, and September 3, 1992, sought clarification of three specific issues related to the enhanced vascular permeability reported in 12-hour KS "lesions" in the Science article by Dr Nakamura and colleagues1: (1) intense diffuse EB staining of tails in untreated but not SP-PG—treated nude mice; (2) easy extraction of extravasated tissue-bound EB-albumin complex using "overnight incubation in PBS at 4°C"; and (3) extraordinarily rapid extravasation of EB-albumin complex into tiny 12-hour KS lesions within 15 minutes of tail vein EB injection.Whereas heightened vascular leakiness, in addition to well-documented lymphatic dysplasia and obstruction,2 may contribute to edema in AIDS-associated KS and angioinhibitory agents theoretically lessen such edema, the report by Nakamura et al in Science, a letter sent by Dr Gallo to Science on June 9,1992, and Science's two tiers


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