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November 3, 1989, Vol 262, No. 17 >

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ARTICLE | November 3, 1989

The Pressor Effect of Phenylpropanolamine

Paul Pentel, MD; Mary Beth O'Connell, PharmD
JAMA. 1989;262(17):2386-2387. doi:10.1001/jama.1989.03430170046021.
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To the Editor. —  Blackburn et al1 cite our data2 as evidence of a controversy regarding the magnitude of effect of phenylpropanolamine (PPA) on blood pressure. We suggest that our data and those of others, including Blackburn et al, are in fact quite consistent; they support the hypothesis that PPA at usual therapeutic doses (25 mg immediate release or 75 mg sustained release) produces little increase in blood pressure but that the dose-response curve is steep. The effect of usual therapeutic doses of PPA on blood pressure of normal subjects has been well studied. Some studies, particularly those that did not measure blood pressure in the supine position, find no increase in blood pressure,3 whereas others note a small increase from 75 mg of sustained-release PPA (5 to 6 mm Hg)1,4 or 25 mg of immediate-release PPA (3 mm Hg).1 Slightly higher doses of PPA

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