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August 11, 1989, Vol 262, No. 6 >
ARTICLE | August 11, 1989

HLA and Immune Response

Candace C. McCombs, PhD; Joseph P. Michalski, MD
JAMA. 1989;262(6):774. doi:10.1001/jama.1989.03430060068021.
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To the Editor.—  We read with interest the article by Weissman et al that reports an association of HLA-DR3, DR4, and DR7 with nonresponsiveness to recombinant hepatitis B vaccine.1 These same HLA-DR antigens have an increased prevalence of celiac disease, a disorder in which an immune response to dietary gliadin seems to underlie the intestinal damage. HLA-DR3 and DR7 have in common a frequent association with the allele DQ2. It now seems that the "primary" association with celiac disease may be that of HLA-DQ2.2-5 It would be interesting to see if the nonresponders with HLA-DR3 and DR7 in the study by Weissman et al also have HLA-DQ2.In the case of celiac disease, a collaborative study by the Ninth Histocompatibility Workshop found that in a group of patients with celiac disease who lacked either DR3 or DR7, some had DQ2 in the absence of DR3 or DR7, while

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