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June 16, 1989, Vol 261, No. 23 >
ARTICLE | June 16, 1989

Transmission of Genital Herpes by Donor Insemination

Donald E. Moore, MD; Rhoda L. Ashley, PhD; Paul W. Zarutskie, MD; Robert W. Coombs, MD, PhD; Michael R. Soules, MD; Lawrence Corey, MD
JAMA. 1989;261(23):3441-3443. doi:10.1001/jama.1989.03420230095034.
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This report describes a donor in a therapeutic donor insemination program who asymptomatically acquired a primary herpes simplex virus type 2 (HSV-2) infection from his long-standing sexual partner. His fresh semen was used to inseminate two HSV-seronegative recipients; in one a primary HSV-2 infection developed, and in one it did not. Direct evidence of transmission from donor to recipient was documented by restriction enzyme analysis of the HSV-2 isolates obtained from the donor's semen and from the recipient's cervix. Because of the possibility of asymptomatic acquisition and transmission of HSV-2, semen donors and their sexual partners should undergo serologic screening for genital herpes using new, type-specific HSV serologic techniques.

(JAMA. 1989;261:3441-3443)

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