April 28, 1989, Vol 261, No. 16 >

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ARTICLE | April 28, 1989

Duration of Immunogenicity and Efficacy of Hepatitis B Vaccine in a Yupik Eskimo Population

Robert B. Wainwright, MD; Brian J. McMahon, MD; Lisa R. Bulkow, MS; David B. Hall, PhD; Mary Anne Fitzgerald, MPH; Annette P. Harpster, RN; Stephen C. Hadler, MD; Anne P. Lanier, MD; William L. Heyward, MD

JAMA. 1989;261(16):2362-2366. doi:10.1001/jama.1989.03420160094029.

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In 1981, a hepatitis B virus vaccine demonstration project was conducted in 1630 Yupik Eskimos in southwest Alaska. Levels of antibody to hepatitis B surface antigen and markers for hepatitis B virus infection in vaccinees were monitored yearly for 5 years. After 5 years of follow-up, 19% of those who initially had an immune response to vaccine of 10 sample ratio units or greater subsequently had levels of antibody to hepatitis B surface antigen lower than 10 sample ratio units. During the 5 years after the first dose of vaccine, in three responders and one person with an antibody to hepatitis B surface antigen response lower than 10 sample ratio units, antibody to hepatitis B core antigen developed, and the level of antibody to hepatitis B surface antigen was boosted. Hepatitis B surface antigen did not develop in any subjects, and none had clinical hepatitis. In the 5 years following the demonstration project, the annual incidence of hepatitis B virus infection decreased from 50 cases per 1000 population before the vaccine trial to 0.45 per 1000.

(JAMA. 1989;261:2362-2366)

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Wainwright RB, McMahon BJ, Bulkow LR, et al. Duration of Immunogenicity and Efficacy of Hepatitis B Vaccine in a Yupik Eskimo Population. JAMA. 1989;261(16):2362-2366. doi:10.1001/jama.1989.03420160094029.

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Duration of Immunogenicity and Efficacy of Hepatitis B Vaccine in a Yupik Eskimo Population

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