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April 14, 1989, Vol 261, No. 14 >
ARTICLE | April 14, 1989

Hib Vaccine Efficacy Trials Continue; Data Needed About Use in Younger Children

Charles Marwick
JAMA. 1989;261(14):2015-2019. doi:10.1001/jama.1989.03420140015004.
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ABSTRACT

PREVENTING Haemophilus influenzae type b by vaccination in the very young is going to have to wait a bit.

Although several new conjugate vaccines have been licensed for use in children 18 months of age and older (JAMA. 1989;261:1152-1153), it appears that additional data from ongoing trials will be needed before these and similar vaccines can be licensed for use in children younger than 18 months.

Several trials are in progress in the United States among infant populations to study the efficacy of newer, more potent versions of H influenzae vaccines that may be successful in protecting children as young as 2 months of age. Children less than 18 months old appear to be the most susceptible to this disease, with about two thirds of cases occurring in this age group. An estimated 20 000 cases of H influenzae occur in the United States each year, with 12 000 cases

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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature

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