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February 10, 1989, Vol 261, No. 6 >
ARTICLE | February 10, 1989

Preliminary Report: 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure to Humans—Seveso, Italy

JAMA. 1989;261(6):831-832. doi:10.1001/jama.1989.03420060031011.
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References

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1 +
Kimbrough RD, ed. Halogenated biphenyls, terphenyls, naphthalenes, dibenzodioxins and related products . New York: Elsevier/ North-Holland Biomedical Press, 1980;:322-48.
2 +
Cerlesi S, Di Domenico A, Ratti S. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) persistence in the Seveso (Milan, Italy) soil. Presented at Dioxin '88, Umea, Sweden, August 21-26,1988.
3 +
Mastroiacovo P, Spagnolo A, Marni E, Meazza L, Bertollini R, Segni G.  Birth defects in the Seveso area after TCDD contamination . JAMA 1988;;259:1668-72.
4 +
Mocarelli P, Marocchi A, Brambilla P, Gerthoux P, Young DS, Mantel N.  Clinical laboratory manifestations of exposure to dioxin in children: a six-year study of the effects of an environmental disaster near Seveso, Italy . JAMA 1986;;256:2687-95.
5 +
Caramaschi F, Del Corno G, Favaretti C, Giambelluca SE, Montesarchio E, Fara GM.  Chloracne following environmental contamination by TCDD in Seveso, Italy . Int J Epidemiol 1981;;10:135-43.
6 +
Pocchiari F, Silano V, Zampieri A.  Human health effects from accidental release of tetrachlorodibenzo-p-dioxin (TCDD) at Seveso, Italy . Ann NY Acad Sci 1979;;320:311-20.
7 +
Facchetti S, Fornari A, Montagna M.  Distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the tissues of a person exposed to the toxic cloud at Seveso . Forensic Environ Appl 1981;;1:1406-44.
8 +
Patterson DG Jr, Hampton L, Lapeza CR Jr, et al.  High-resolution gas chromatographic/high-resolution mass spectrometric analysis of human serum on a whole-weight and lipid basis for 2,3,7,8-tetrachlorodibenzo-p-dioxin . Anal Chem 1987;; 59:2000-5.
9 +
Patterson DG Jr, Needham LL, Pirkle JL, et al.  Correlation between serum and adipose tissue levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin in 50 persons from Missouri . Arch Environ Contam Toxicol 1988;;17:139-43.
10 +
 CDC Veterans Health Studies. Serum 2,3,7,8-tetrachlorodibenzo-p-dioxin levels in US Army Vietnam-era veterans . JAMA 1988;;260:1249-54.
11 +
CDC.  Serum 2,3,7,8-tetrachlorodibenzo-p-dioxin levels in Air Force Health Study participants—preliminary report . MMWR 1988;;37:309-11.
12 +
Fingerhut M, Sweeney M, Patterson D, Marlow D, Hornung R, Halperin W. Levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the serum of U.S. chemical workers exposed to dioxin-contaminated products. Presented at Dioxin '88, Umea, Sweden, August 21-26,1988.
13 +
Beck H, Eckart K, Mathar W, Ruhl C-S, Wittkowski R. Levels of PCDDs and PCDFs in adipose tissue of occupationally exposed workers. Presented at Dioxin '87, Las Vegas, Nevada, October 4-9, 1987.
14 +
Pirkle JL, Wolfe WH, Patterson DG Jr, et al.  Estimates of the half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Ranch Hand Veterans . J Environ Health Toxicol (in press).
15 +
Zone R was originally thought to be a reference zone, but on subsequent detection of TCDD concentrations in soil, Zone S was added.
16 +
Levels of TCDD in serum or adipose tissue of the general population are less than 20 ppt.

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