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Extended Preservation of Human Liver Grafts With UW Solution

Satoru Todo, MD; Jose Nery, MD; Katsuhiko Yanaga, MD; Luis Podesta, MD; Robert D. Gordon, MD; Thomas E. Starzl, MD, PhD
JAMA. 1989;261(5):711-714. doi:10.1001/jama.1989.03420050061039.
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The fate of 185 cadaveric liver homografts preserved for four to 24 hours with University of Wisconsin (UW) solution was compared with that of 180 grafts preserved for three to 9 1/2 hours with conventional Euro-Collins solution. Although the average preservation time of the UW-preserved livers was almost twice as long as that of the Euro-Collins-preserved livers, the UW-preserved grafts survived at a higher rate; permitted equal patient survival; and had a lower rate of primary nonfunction, a reduced need for retransplantation, and a lower rate of hepatic artery thrombosis. There was no correlation between the time of preservation of UW-preserved grafts up to 24 hours and liver function abnormalities in the first postoperative week. In contrast, livers preserved with Euro-Collins solution for more than five hours had significantly increased perturbations of hepatic function tests. The potential revolutionary effect of the UW solution on liver transplantation is described herein.

(JAMA 1989;261:711-714)


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