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The Restless Tide: The Persistent Challenge of the Microbial World

Mary Lou Clements, MD, MPH
JAMA. 1982;248(2):241-242. doi:10.1001/jama.1982.03330020077043.
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The Restless Tide, a collection of delightful essays, provides an absorbing overview of the historical origins of and recent advances in microbiology and immunology. The book also addresses issues concerning the usefulness of biomedical research and the quality of medical education and medical care. These essays were adapted from public lectures that the author delivered during his first five years as director of the National Institute of Allergy and Infectious Diseases at the National Institutes of Health.

Written in an entertaining, narrative style, these 11 essays present a current and broad perspective on different aspects of medicine. Each recalls the origins of current achievements, traces their evolution, gives an up-to-date account of each field discussed, and comments on the future research strategies required for over-coming present obstacles. Topics covered include recent advances in the control of infectious diseases by treatment or immunizations; the chameleon nature of microbes—shifts in antigenic constitution


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