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Captopril and Hypertension

Daniel T. O'Connor, MD
JAMA. 1981;245(23):2453. doi:10.1001/jama.1981.03310480063039.
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This volume, the proceedings of a conference on captopril and hypertension, aims to cover three areas: (1) the physiology of blood pressure control and its alterations in hypertension, (2) the development of angiotensinconverting enzyme inhibitors, and (3) the clinical use of converting enzyme inhibitors.

The chapters are well organized and lucidly written by noted authorities in each field. The chapters in section 1 are not especially germane to converting enzyme inhibition, but do provide up-to-date and informative glimpses of several areas of blood pressure research.

Sections 2 and 3, on converting enzyme inhibitor development and clinical use, are in large part reprinted from the journal Progress in Cardiovascular Diseases, late 1978, which published a symposium on captopril at that time. Chapters on the clinical use of captopril are somewhat slanted, and perhaps slightly out of date, in that they focus only on blockade of the renin system as the antihypertensive


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