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Congenital Cytomegalovirus Infection in One Monozygotic Twin

John Seguin, MD; Cheng T. Cho, MD, PhD
JAMA. 1988;260(22):3277. doi:10.1001/jama.1988.03410220061021.
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To the Editor.—  Congenital cytomegalovirus (CMV) infections have been described in one1,2 and both3,4 dizygotic twins, as well as in both monozygotic twins.5 Infection affecting only one monozygotic twin has not been reported. We describe such a case.

Report of a Case. —  The mother of the twins was referred to us because of discordant size. Ultrasonography two days before delivery revealed one twin consistent with 32 weeks' gestation and the other consistent with 26 weeks'. No dividing membrane was seen. Delivery by cesarean section was planned because of the morbidity and mortality associated with discordant twins.The first twin was a 2260-g girl, with a head circumference of 31 cm and a length of 44 cm. She required supplemental oxygen for 12 hours of life. A urine culture obtained on the third day was negative for CMV.The second twin was a 710-g girl, with a


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