We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Reflux Nephropathy

Samuel Vaisrub, MD
JAMA. 1981;245(23):2430. doi:10.1001/jama.1981.03310480046030.
Text Size: A A A
Published online


Although ureterovesical reflux in children was described as early as 1897,1 and the glomerular changes that often ensue if these children survive to adulthood were noted half a century ago,2 reflux nephropathy—a term embracing both the etiology and the sequel—is still incompletely understood. Currently, however, with opportunities provided by improved histological and histoimmunologic techniques, this condition is undergoing extensive investigation.

Two recent studies—one from Lexington, Ky,3 the other from the Mayo Clinic4—shed more light on the development of reflux nephropathy and its response to renal transplantation. Their conclusions are not always in accord.

Bhatena et al3 of the Lexington group studied 23 patients with reflux nephropathy between 1973 and 1977. All 23 underwent nephrectomies with subsequent renal transplantation, and all manifested focal and segmental glomerulosclerosis in their native kidneys. The lesions appeared to evolve from early glomerular hypertrophy to focal and segmental and occasionally


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.