Dysplasia in Crohn's disease may indicate cancer

JAMA. 1981;245(23):2385. doi:10.1001/jama.1981.03310480009005.
Text Size: A A A
Published online


Unequivocal dysplastic changes in patients with Crohn's disease should perhaps be considered an indication for cancer surgery, according to a report from a group at the University of Chicago/the Pritzker School of Medicine.

"It's too early for general recommendations," says Shannon Simpson, MD, a senior resident in pathology, "but the cancer we see in patients with Crohn's disease is especially vicious, so it may be that early surgery is indicated."

Simpson and colleague Robert Riddell, MD, presented a report on intestinal adenocarcinoma and dysplasia in Crohn's disease at the 70th annual meeting of the International Academy of Pathology in Chicago. Simpson said they had studied six patients with both conditions and that adenocarcinoma was found in the ileum, ileocecum, sigmoid, and rectal stump. In one of the six, the cancer was at a previous anastomosis site.

"Intestinal cancer is difficult to detect preoperatively," Simpson noted, "because the x-ray changes resulting


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.