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The Patient With Multiple Alloantibodies

Peter D. Issitt, FIMLS, MIBiol, MCRPath; Peter A. Tomasulo, MD
JAMA. 1982;248(2):169. doi:10.1001/jama.1982.03330020015008.
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To the Editor.—  A recent report by Patten and Conti in The Journal (1982;247:209) described collection of 10 units of blood in a 17-week period from a woman who was said to be the only compatible donor for the patient, her sister. The data given leave doubts as to whether the heroic efforts on the part of the donor were really necessary.First, a week after infusion of 3 units of blood, the patient suffered a delayed hemolytic transfusion reaction. Her serum was found to contain anti-C, anti-E, anti-Jkb and an antibody of "uncertain specificity" that reacted with an antigen of high incidence. This last antibody was believed to be the "most likely cause" of the reaction, but no data on which this conclusion was based are given. Did the anti-Jkb play any role in the reaction? Antibodies in the Kidd system have many times caused delayed transfusion


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