We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Chemoembolization: Transcatheter Management of Neoplasms

Vincent P. Chuang, MD; Sidney Wallace, MD
JAMA. 1981;245(11):1151-1152. doi:10.1001/jama.1981.03310360043023.
Text Size: A A A
Published online


"Chemoembolization," the combination of intra-arterial infusion of a chemotherapeutic agent and arterial embolization of the vascular supply to a neoplasm as proposed by Kato et al elsewhere in this issue (p 1123), presents an interesting concept with considerable potential. In addition to the direct effect of ischemia on the neoplasm by temporary occlusion, the emboli decrease the transit time through the tumor vascular bed, theoretically increasing the contact time of the chemotherapeutic agent with the neoplastic cell, increasing local drug concentration, and probably increasing tissue permeability because of the anoxia. The cytotoxic effect is not only on the neoplasm, but on the vessel embolized and infused, producing vasculitis and occlusion. The systemic toxic effect may be reduced by metabolism of the drug on its first passage through the infused organ, thereby confining the higher concentration of the chemotherapeutic agent to the target organ.

There is considerable clinical support for each


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.