0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Primary Prevention With Metoprolol in Patients With Hypertension-Reply

John Wikstrand, MD, PhD; Ingrid Warnold, PhD; Gunnar Olsson, MD, PhD; Jaakko Tuomilehto, MD, PhD; Dag Elmfeldt, MD, PhD; Göran Berglund, MD, PhD
JAMA. 1988;260(12):1715-1716. doi:10.1001/jama.1988.03410120059021.
Text Size: A A A
Published online

In Reply.—  The protocol for the trial of β-blockers vs diuretics in hypertension was defined in 1975. All centers randomized patients either to metoprolol or a diuretic counterpart, with the exception of one center with 46 patients taking propranolol (atenolol was not included as an option in the original study). More than two years after the first patient was randomized, a separate part randomizing patients to atenolol or diuretics was started (Fig 2). Many patients were followed up for only one year in this part, partially explaining a low mortality rate, probably about six deaths per 1000 patient-years in the diuretic-treated group. That tendencies in one or the other direction may occur when mortality rates are low, as in the part comparing atenolol with diuretics, might be expected by chance. This does not change the interpretation of the results of the MAPHY Study since, as pointed out by the chairman

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();