0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Primary Prevention With Metoprolol in Patients With Hypertension

Ray W. Gifford Jr, MD
JAMA. 1988;260(12):1714-1715. doi:10.1001/jama.1988.03410120059017.
Text Size: A A A
Published online

To the Editor.—  The design of the Metoprolol Atherosclerosis Prevention in Hypertensives (MAPHY) Study1 is as unorthodox as the results are surprising.How can deletion of the half of the original cohort from centers not electing to use metoprolol as the β-blocker in the Heart Attack Primary Prevention in Hypertensives (HAPPHY) trial and extension of the period of observation for only 15 months yield findings so disparate from those of the parent HAPPHY trial? If smoking men randomized to metoprolol treatment in the MAPHY Study had a significantly lower mortality rate than those randomized to diuretic treatment, yet in the HAPPHY trial there was no difference in mortality between men taking β-blocker (metoprolol or atenolol) and those taking diuretics, irrespective of smoking habits, it seems inescapable that in the atenolol group that was deleted from the MAPHY Study the mortality rate must have been significantly higher for men taking the

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();