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Brucellosis Outbreak at a Pork Processing Plant—North Carolina, 1992

JAMA. 1994;271(22):1734-1735. doi:10.1001/jama.1994.03510460026011.
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This test uses a B. abortus antigen to detect infections with B. abortus, B. melitensis, and B. suis.
The use of 2-ME in the STA disrupts the disulfide bonds of immunoglobulin M and allows measurement of only immunoglobulin G (IgG), which appears within weeks after infection. In patients who have been adequately treated and achieved a clinical cure, IgG generally declines, although it can persist for up to 1 year; in the absence of adequate treatment, IgG usually persists. IgG, as detected by the 2-ME test, is therefore used as a marker for persistent or recent infection.
The case definition used in this investigation differs from the national surveillance case definition, which is based on a compatible clinical illness supported by culture or serologic evidence.
Brucella species known to cause human disease (and their usual reservoir hosts) are: B. abortus (cattle), B. canis (dogs), B. melitensis (goats and sheep), and B. suis (swine). The distribution of disease caused by the various Brucella species varies from region to region.


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