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Risk Factors for Ectopic Pregnancy-Reply

Polly A. Marchbanks, PhD; John F. Annegers, PhD; Carolyn B. Coulam, MD; Janette H. Strathy, MD; Leonard T. Kurland, MD, DrPH
JAMA. 1988;260(11):1554. doi:10.1001/jama.1988.03410110061020.
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In Reply.—  The comments by Drs Weiss and Daling give us an opportunity to elaborate on the interpretation of our study findings. There are two distinct research issues concerning the association between ectopic pregnancy and current IUD use: (1) the relative risk of ectopic implantation given that conception has occurred and (2) the relative risk of conception followed by ectopic implantation. The second relative risk is intrinsically tied to the relative risk of conception itself, while the first relative risk is not. Different control groups are required to assess these separate but related associations. We agree with Drs Weiss and Daling that a nonpregnant control group is required to evaluate the relative risk of conception followed by ectopic implantation. However, our study was not designed to assess this issue. Rather, our study was designed to assess the relative risk of ectopic implantation given that conception has occurred. To evaluate the

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