We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......

Fluorouracil for Colorectal Cancer: A Sobering Look

Merrill S. Kies, MD
JAMA. 1982;247(20):2826. doi:10.1001/jama.1982.03320450060039.
Text Size: A A A
Published online


Colorectal cancer is the most common visceral malignant neoplasm in the United States and will affect an estimated 123,000 persons in 1982. While surgical resection remains the only generally accepted curative therapy, the impetus for development of effective treatment for systemic disease continues because more than half the patients eventually have widely disseminated cancer. In this issue of The Journal Levine and colleagues (p 2809) describe a patient with well-documented hepatic metastases who survived for 15 years. The rub, as the authors point out, is that we understand very little about why occasional patients with metastatic colon cancer have extended survival, with or without therapy, when median survival is only seven to nine months. Similarly, we have little understanding of the determinants of tumor growth rates or patterns of metastases.

The chemotherapy of colorectal cancer has for two decades involved fluorouracil alone and in multidrug combinations. Clinical researchers have exhaustively


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.