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Brain Metastasis

Kurt A. Jaeckle, MD
JAMA. 1980;244(23):2671-2672. doi:10.1001/jama.1980.03310230065036.
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This authoritative volume on diagnosis and treatment of brain metastasis is the second in a series on metastasis and is the product of a workshop at the Memorial Sloan-Kettering Cancer Center in September 1978.

After an excellent introductory chapter that serves as an "overture," the book is subsequently divided into three sections. The first section deals with the basic pathophysiological mechanisms underlying the phenomenon of brain metastasis and explores current research in such areas as experimental metastasis, modes of spread and the "cascade" process, brain tumor microvasculature and the blood-brain barrier, and principles of chemotherapy and immunology. The second section reviews the currently available clinical and radiological methods used in the diagnosis of brain metastasis and includes a timely chapter on positron-emission tomography. The third section, on treatment, is extensive and current. It begins with an analysis of the benefit of palliative management from an ethical standpoint.

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