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The Hypoglycemia Index-Reply

Debra D. Johnson; Kay E. Dorr, MA, MS, PhD; Wendell M. Swenson, PhD; F. John Service, MD, PhD
JAMA. 1980;244(23):2608-2609. doi:10.1001/jama.1980.03310230014012.
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In Reply.—  When the article by Hadji-Georgopoulos et al1 appeared, we applied their hyopglycemic index to the oral glucose tolerance test (OGTT) results of our group of patients. The calculation was done by dividing the slope of glucose descent after the peak by the glucose nadir (units=hr—1). This varies from the method of Hadji-Georgopoulos et al only in the time interval for slope determination and can be compared by dividing their values by 1.5.Probably because our series was larger (192 vs 28 patients), we did observe patients without symptoms of hypoglycemia at glucose nadirs <50 mg/dL in contrast to the observation of the group in Baltimore. For the 44 patients with glucose nadirs <50 mg/ dL and the 93 patients with glucose nadirs between 50 and 65 mg/dL (the range recommended for use of the hypoglycemic index1), there was no difference in the hypoglycemic index for


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