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Influenza Vaccination of Elderly Persons Reduction in Pneumonia and Influenza Hospitalizations and Deaths

William H. Barker, MD; John P. Mullooly, PhD
JAMA. 1980;244(22):2547-2549. doi:10.1001/jama.1980.03310220045026.
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Effectiveness of influenza vaccination in reducing pneumonia and influenza hospitalizations and deaths among elderly members of a prepaid health plan was analyzed retrospectively. Two epidemics caused by the H3N2 subtype of type A influenza were studied. Vaccine derived from the H2N2 subtype of influenza A virus failed to protect against the Hong Kong (H3N2) virus during the 1968-1969 epidemic. Vaccine derived from the A/Hong Kong/68 (H3N2) virus yielded an estimated 72% (31% to 100%) reduction in hospitalization and 87% (52% to 100%) reduction in mortality during the 1972-1973 epidemic caused by A/England/72 (H3N2). These findings are consistent with those reported in vaccinated young persons, and hence it appears they may be broadly generalized.

(JAMA 1980;244:2547-2549)


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