Serum CPK Elevation After Seizures

Andrew L. Chesson, MD; Edward J. Kasarskis, MD, PhD
JAMA. 1980;244(21):2414-2415. doi:10.1001/jama.1980.03310210016011.
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To the Editor.—  Serial determination of serum creatine phosphokinase (CPK) level is a useful index of acute myocardial infarction.1 Nevertheless, a rise in serum CPK level must be interpreted with caution, because many extracardiac conditions are recognized to cause CPK level elevation (1974;229:1894).1 We wish to call attention to the time course of serum CPK level elevation after generalized, tonic-clonic convulsions.We have determined serum CPK levels in five nonalcoholic patients who were admitted to the hospital for examination immediately after their first seizure. Three patients had generalized tonic-clonic seizures, and two had repetitive focal motor seizures involving the face or eralized tonic-clonic seizures, and two had repetitive focal motor seizures involving the face or extremity. Seizures were observed by either a physician or another reliable witness. No intramuscularly given injections were administered. There was no previous history of neuromuscular disease in any patient. Serial ECGs did not


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