0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Colorectal Cancer Chemotherapy: Meta-analysis or Large-Scale Trials?

Bernard Levin, MD; Michael J. O'Connell, MD
JAMA. 1988;259(24):3611. doi:10.1001/jama.1988.03720240073039.
Text Size: A A A
Published online

In this issue of JAMA, Buyse and colleagues1 present a meta-analysis of adjuvant therapy for colorectal cancer. They have previously provided information about meta-analysis,2 which is a new discipline that statistically combines and critically reviews the results of previous research. The purposes of meta-analysis include the following: (1) to increase statistical power for primary end points and for subgroups, (2) to resolve uncertainty when reports disagree, (3) to improve estimates of effect size, and (4) to raise and possibly answer questions not posed at the start of individual trials.

In this comprehensive review, Buyse and coworkers1 have assembled all randomized, controlled, clinical trials on adjuvant therapy for colorectal cancer published up to December 1986 in the English language. They excluded nonrandomized and "immature" trials and those using adjuvant liver perfusion. Among the 27 trials found, eight trials compared radio

See also p 3571. therapy with (surgical) control

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Figures

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();