0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Captopril and Digoxin in Mild to Moderate Heart Failure-Reply

Bertram Pitt, MD; Sidney Goldstein, MD
JAMA. 1988;259(24):3557-3558. doi:10.1001/jama.1988.03720240019014.
Text Size: A A A
Published online

ABSTRACT

In Reply.  —In response to the letter by Dr Zatuchni regarding our recent publication in JAMA, we agree with the difficulties in assessing end points in clinical trials for congestive heart failure. Treadmill exercise testing and New York Heart Association classification constitute the universally accepted end points in clinical trials. Improvements in these parameters were in fact the basis of approval in 1982 by the Food and Drug Administration for the use of captopril in the treatment of heart failure refractory to treatment with digitalis and diuretics.Because of the subjective nature of the assessment of exercise tolerance and functional class, the validity of the conclusions rests on double-blinding the investigation in addition to randomly allocating treatments to patients. The random allocation of treatments allows the chance distribution of "whim and will" among the treatment groups and is the prerequisite for making statistical inferences from the study. Clearly, measuring exercise

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Figures

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();