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Pulmonary Shunting During Leukoagglutinin-lnduced Noncardiac Pulmonary Edema

Michel Dubois, MD; Michael T. Lotze, MD; William J. Diamond, MD; Young D. Kim, MD; M. Wayne Flye, MD; Thomas E. Macnamara, MB, ChB
JAMA. 1980;244(19):2186-2189. doi:10.1001/jama.1980.03310190038019.
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Noncardiogenic pulmonary edema occurred in an anesthetized patient during an otherwise uneventful laparotomy. Following transfusion of an individual unit of whole blood, routine intraoperative monitoring detected sudden major pulmonary shunting (increased alveolar-arterial oxygen gradient) and an increased physiological alveolar dead space (increased arterial-alveolar carbon dioxide gradient). The noncardiac pulmonary edema probably resulted from the presence of a leukoagglutinin against the patient's granulocytes in the donor's plasma. This antibody had no apparent specificity for known HLA, neutrophil, or blood group antigens. The acute respiratory failure was transient, resolving in 72 hours with respiratory support. The presence of otherwise unexplained noncardiogenic pulmonary edema during or soon after a blood transfusion should suggest the possible diagnosis of a leukoagglutinin reaction.

(JAMA 244:2186-2189, 1980)


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