We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Cellular Mechanisms of Benzodiazepine Action

Robert E. Study, PhD; Jeffery L. Barker, MD
JAMA. 1982;247(15):2147-2151. doi:10.1001/jama.1982.03320400059039.
Text Size: A A A
Published online


BENZODIAZEPINES are in common clinical use because they possess a fortunate combination of important therapeutic properties. They are effective in the treatment of two common clinical conditions—anxiety and insomnia—and they are useful in the treatment of seizure disorders and certain kinds of spasticity as well. In addition to these therapeutic actions, these drugs lack significant side effects outside of the CNS and have low toxicity, factors that have contributed to their widespread clinical use. Since the introduction of chlordiazepoxide hydrochloride (Librium) in 1960, research into the cellular mechanisms of benzodiazepine action has increased in parallel with the use of these agents. In this review, some recent advances in elucidating the mechanisms of action of benzodiazepines in the CNS are described. The principal lines of basic research on benzodiazepines fall into two general categories: biochemical and electrophysiological. Although they will be discussed separately, they represent complementary strategies for achieving a comprehensive


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.