We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......

Congenitally hypothyroid mice yield clues for man

Gail McBride
JAMA. 1982;247(15):2077-2078. doi:10.1001/jama.1982.03320400007003.
Text Size: A A A
Published online


What appears to be a good animal model for 80% of cases of human congenital hypothyroidism is being studied intensively at The Jackson Laboratory, Bar Harbor, Me, and a dozen or so other laboratories.

Wesley Beamer, PhD, a staff scientist at The Jackson Laboratory, first discovered the mutation around the end of 1975 in a female laboratory mouse, although he first thought it was a deficiency of growth hormone. Further breeding of the mouse and its progeny led to the conclusion that the phenotype was due to an autosomal recessive gene. Eva Eicher, PhD, also of the laboratory, then mapped the gene to chromosome 12 in the mouse. (The gene or genes that may be related to some or all cases of human congenital hypothyroidism have not been mapped.)

Thyroid glands in the affected (hyt/hyt) mice are of small size and very hypoplastic, similar to those in 80% of infants


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.