We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

A History Lesson: Hepatitis Is Not Always What It Seems

Geoffrey M. Zucker, MD; Charles B. Clayman, MD
JAMA. 1982;247(14):2011. doi:10.1001/jama.1982.03320390073051.
Text Size: A A A
Published online


Two unusual hepatic presentations of otherwise common infectious diseases are reported in this issue of The Journal (pp 1999 and 2000). They illustrate that while viral A, B, and non-A, non-B acute hepatitis are ubiquitous, there are other infectious agents associated with hepatitis. The clinician must therefore consider other diagnostic possibilities among different age groups.

In the neonate, cytomegalic inclusion-virus is a major cause of fetal and infant morbidity, followed by rubella (congenital or acquired) and herpes simplex (type 2 more than type 1).1 Hepatitis seen with these viral illnesses is usually associated with other physical findings that may aid in their diagnosis. The presence of associated heart disease, pneumonitis, retinopathy, bleeding diathesis, or skin changes may be important clues to the nature of the viral illness. When acute hepatitis alone is present in the neonate, and viral isolation and serological findings are negative, metabolic or hereditary causes should


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.