We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......

Virilizing Adrenal Adenoma in a 15-Year-Old Girl

Phillip D. K. Lee, MD; Orville C. Green, MD
JAMA. 1988;259(10):1497-1498. doi:10.1001/jama.1988.03720100019022.
Text Size: A A A
Published online


To the Editor.  —In a recent issue of JAMA, Kamilaris et al1 presented a case of a virilizing adrenal adenoma associated with an elevated testosterone level occurring in a 15-year-old girl. According to the authors, this represents the second youngest patient with a testosterone-secreting adrenocortical adenoma.We have reported elevated levels of testosterone in eight pediatric patients with virilizing adrenocortical tumors,2 and our review of the literature revealed several previous reports. Cacciari et al3 subsequently have reported nine similar cases. In fact, virilizing adrenocortical tumors in children are almost invariably associated with elevated testosterone levels, and measurement of this hormone may provide an important diagnostic and therapeutic marker. As noted by Kamilaris et al and others,4 urinary 17-ketosteroid levels, as measured by the Drekter method, are variable in this situation. We found elevated urinary 17-ketosteroid levels in all eight of our patients by using a modification


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.