Knowledge of disease, uncertainty about prognosis, and toxic therapy are all adequate causes for a reactive depression. Oncologists are well aware of these facts. However, once patients achieve remission in Hodgkin's disease, these stresses are greatly eased.In our study, we noted the symptoms stated in women who had documented estrogen deprivation. The women with normally functioning ovaries did not report any of these symptoms. Some of the symptoms are a direct physiological result of estrogen depletion, and some may be caused by a reactive depression to these bodily changes. However, the originating factor appears to be estrogen deprivation. Therefore, the primary treatment logically should be aimed at the cause of the illnessestrogen replacement and counseling of patient and spouse. If any depressive symptoms persist after these measures have been taken, then consideration of treatment with antidepressants may well be in order.